Scientific direction Development of key enabling technologies
Transfer of knowledge to industry

PhD : selection by topics

Technological challenges >> Health and environment technologies, medical devices
4 proposition(s).

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Point-of-Care medical device development for high sensitivity multiplexed detection of blood biomarkers for health care management of cardiac patients

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Biologie et Architecture Microfluidiques

01-09-2020

SL-DRT-20-0451

myriam.cubizolles@cea.fr

Health and environment technologies, medical devices (.pdf)

Health systems must adapt to new societal and economic constraints that constitute an important challenge to address for the health of tomorrow. In this context, the development of Point-of-Care (POC) devices to carry out in vitro analyses provide valuable assistance to the decision-making of the practitioner for the diagnosis and/or prognosis of the disease. In this context, we propose a PhD subject to explore a new strategy to quantify blood biomarkers (proteins, peptides). This strategy is an alternative to the ELISA gold standard method, based on immuno-detection coupled to enzymatic amplification. We propose an innovative approach to develop a medical device for the high sensitivity detection of various significant blood biomarkers for cardiac diseases. The employed strategy is based on the use of original reagents (aptamers) allowing an isothermal multiplex biomolecular amplification, fast and highly sensitive, coupled with protocol integration and automation inside dedicated microfluidic cartridges. The developed biomedical device will be tested on clinical samples.

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Antimicrobial functionalization of nanostructures by initiated Chemical Vapor Deposition

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Chimie, Capteurs et Biomatériaux

01-10-2020

SL-DRT-20-0814

guillaume.nonglaton@cea.fr

Health and environment technologies, medical devices (.pdf)

The production of antimicrobial and antibiofouling surfaces without antibiotics or nanoparticles is still a challenge despite the needs of a growing number of applications, particularly in the hospital field and more specifically for implanted medical devices. The number of patients infected each year with nosocomial diseases is still too high and infections related to implanted medical devices remain an unresolved problem. The limit of current solutions is their very short lifetime and their rapid fouling by biofilm generation. The scientific community increasingly studied bio-inspired coatings made of polymers with antimicrobial, antibiofouling or switchable functions. However, these coatings are still difficult to achieve by green chemistry on structured surfaces using conventional methods. Initiated Chemical Vapor Deposition (iCVD) is a unique technique for producing polymeric surface coatings on micro structured surfaces while retaining the chemical functions of polymers. The aim of this thesis is to study the feasibility of iCVD deposition of bioinspired polymers with a double switchable function antimicrobial and antibiofouling on nanostructures. The candidate will have a profile of material chemist or polymer chemist with a strong affinity for microbiology and health applications with a MSc in material chemistry or polymer chemistry.

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Bio sensir using near field propagation of millimeter waves

Département Architectures Conception et Logiciels Embarqués (LIST-LETI)

Laboratoire Architectures Intégrées Radiofréquences

01-10-2020

SL-DRT-20-0933

frederic.hameau@cea.fr

Health and environment technologies, medical devices (.pdf)

In the context of new bio-medical applications, we propose to use solutions from the radio-frequency domain, namely using millimeter wave systems, which had to radiate with nearfield antenna. Depending on the antenna neighborhood, the behavior of the radiated wave changes with its frequency and amplitude. This PhD aims to detecte physiological parameters using this signature of the environnement at different wavelength, signal amplitude and even signal shape (chirp). This physiological parameter could be the sweat, the hartbeat, melanoma, but not only. Target frequency could be from 20GHz to 120GHz which are easy for CMOS integration. From an existing study, the PhD student will have to developpe an accurate solution, which could be based on the antenna impedance variation due to the environement (Power Amplifier output impedance modification tracking) or the analysis of the reflected signal thought a polar receiver (radar mode).

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Evaluation of photobiomodulation properties to optimize organ transplant

Clinatec (LETI)

Clinatec (LETI)

01-11-2020

SL-DRT-20-1236

cecile.moro@cea.fr

Health and environment technologies, medical devices (.pdf)

Grafts do not always meet the eligibility criteria, thus limiting the number of grafts available. One way to increase this number would be to repackage "borderline" grafts and / or protect them from the damage inherent in the transplantation protocol (in particular due to the ischemia-reperfusion processes), and to promote the phenomena of revascularization and scarring. An innovative light therapy, photobiomodulation, could optimize and protect these grafts. Here we wish to assess the therapeutic potential of photobiomodulation in several preclinical transplantation models. Complementary cell biology studies will allow a better understanding of the mechanisms used. This research program will cover several therapeutic areas, and will be carried out in conjunction with multidisciplinary research teams outside the CEA.

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