Scientific direction Development of key enabling technologies
Transfer of knowledge to industry

PhD : selection by topics

Technological challenges >> Health and environment technologies, medical devices
8 proposition(s).

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Wearable dynamic fluidic chamber dedicated to transcutaneous monitoring of oxygen and carbon dioxide blood concentration

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Systèmes Pour la Personne

SL-DRT-21-0415

rodrigue.rousier@cea.fr

Health and environment technologies, medical devices (.pdf)

The development of wearable medical devices is a fundamental and essential in order to promote ambulatory medicine. So-called "conventional" as opposed to outpatient medicine commonly uses blood gas analysis to assess the efficiency of pulmonary exchanges and diagnose respiratory diseases. In particular, it detects an abnormal change in the oxygen and carbon dioxide concentrations in arterial blood going to the tissues. Since this analysis requires a blood test, it is therefore an invasive method and does not allow monitoring of concentrations in real time. An alternative to taking blood is a transcutaneous gas analysis, i.e. measuring the concentrations of gases that diffuse through the skin. This method is non-invasive and guarantees continuous monitoring of blood gases. The objective of this thesis is to study and develop an instrumented wearable dynamic fluidic chamber. This chamber will measure in real time the concentrations of oxygen and carbon dioxide which diffuse through the skin. The work will consist in modeling the gas exchanges between the skin and the fluidic chamber, then designing and instrumenting the chamber and finally testing it on a gas test bench. This subject requires a highly motivated person with skills in simulation, medical device design and instrumentation.

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Elastic wave sensors for field biological detection

Département Composants Silicium (LETI)

Laboratoire Composants Radiofréquences

01-09-2021

SL-DRT-21-0437

alexandre.reinhardt@cea.fr

Health and environment technologies, medical devices (.pdf)

Monitoring of the sanitary quality of water becomes increasingly a public health issue. In this context, CEA-LETI is developping sensors to detect bacteria in liquid samples. Among the technologies under investigation, electromechanical elastic wave sensors appear as particularly promissing. The aim of this PhD is to evaluate the use of such components, initially developped for radiofrequency signal processing, to biological detection in liquid samples. More precisely, the PhD subject proposed aims in a first stage at analysing the biological structures we want to detect, their possible interactions with a sensors and the associated detection mechanisms which could be exploited. This will allow the design of suitable sensors, by selecting the type of resonator, the vibration mode leading to the highest sensitivity and compatible with operation in liquids, and a scheme for the electronic readout of the sensor output. The candidate will then fabricate prototypes in the CEA-LETI clean rooms and will functionalize them and evaluate their performance in the laboratory. Ultimately, the sensors will be adapted so that they can be integrated in a multi-sensors detection platform developped in parallel by the CEA-LETI teams.

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Development of biofunctionalized photonic circuits for the analysis of volatile organic compounds at very low concentrations for environmental and medical applications

Département d'Optronique (LETI)

Laboratoire des Capteurs Optiques

01-10-2021

SL-DRT-21-0473

loic.laplatine@cea.fr

Health and environment technologies, medical devices (.pdf)

The identification and quantification of volatile organic compounds (VOCs) in the air is a crucial issue in many fields. The analysis of outdoor air makes it possible, for example, to monitor and control pollution linked to industry or motorway traffic. Likewise, the analysis of exhaled air allows the diagnosis of certain pathologies. This requires the ability to measure dozens of different VOCs at very low concentrations (ppb) in complex gas matrices. CEA Grenoble recently developed sensors using integrated silicon photonic circuits chemically functionalized by biomolecules capable of specifically capturing certain VOCs, similar to human olfaction. They are currently used for measuring odors. These biomimetic photonic sensors offer great potential in terms of miniaturization, improvement in sensitivity, multiplexing for the measurement of complex mixtures, and can be manufactured at low cost by methods derived from microelectronics. In particular, they make it possible to consider gas analyzes in situ and in real time. The thesis is positioned at the frontier of electronic noses and analytical systems and will aim at the design and instrumentation of an experimental device to improve the detection limit and identification. The thesis will be highly multidisciplinary and will include the design and characterization of integrated photonic circuits on wafers and chips, the design and characterization of microfluidic circuits, surface chemistry and biofunctionalization, as well as data analysis (classification, modeling, learning, etc?). We will explore certain applications at the end of the thesis, in particular on the analysis of exhaled air and the detection of atmospheric pollutants.

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On-Chip moniToring of Organoids using an oPtoflUidiC systEm

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Chimie, Capteurs et Biomatériaux

01-10-2021

SL-DRT-21-0534

charlotte.parent@cea.fr

Health and environment technologies, medical devices (.pdf)

The thesis is positioned in the domain of organoids, which enable fundamental tissue mechanisms to be studied in-vitro. The project aims at developing a new microfluidic system with integrated simple, robust and compact optical reading, and allowing for in-situ monitoring of the secretome evolution during the cell culture. The chosen model system is the culture of islets of Langerhans responsible for the endocrine function of the pancreas and playing an important role in diabetes. To reach our objective, we propose to combine two approaches within a microfluidic chip: a chip with photonic-crystal sensors that are compatible with lens-less optical reading (LED + CMOS), and a microfluidics technology integrating the pneumatic actuation of an elastic membrane. The main challenges of the project are related to the sensors sensitivity, the optical chip integration in the microfluidic system and the sampling of aliquots without perturbation of the organoid. The thesis will be in collaboration between two complementary laboratory, CEA-LETI (microfluidics, technology), and INL (photonic biosensors).

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Fast detection of AMR bacteria in water through mid-IR imaging and isotope probing

Département d'Optronique (LETI)

Laboratoire des Capteurs Optiques

01-10-2021

SL-DRT-21-0678

mathieu.dupoy@cea.fr

Health and environment technologies, medical devices (.pdf)

Currently the challenge is to develop automatic and non-invasive measurements to enhance early identification or diagnosis. The optical technologies are the label free methods to detect and identify the chemical composition of the sample. Infrared spectroscopy is a widespread and reliable method to obtain a spectral fingerprint of the sample based on absorption of Mid-IR light. An optical platform has been developed to measure the absorption of light through the sample, combining quantum cascade laser (QCL) and bolometer matrix. The objective of the thesis is to explore the potential of Mid-IR imaging and isotope probing to assess the bacteria antimicrobial resistance. The thesis will aim to create the biological protocol mixing the isotope probe and the constraints of infrared radiation, to carry out the images on several bacteria species, to implement the data processing algorithms in order to evaluate the relevance of this approach.

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Additive manufacturing of biocompatible and bioresorbable microfluidic scaffolds for the development of implantable organ-on-chip (OoC) systems

Département des Technologies des NanoMatériaux (LITEN)

Laboratoire de Formulation des Matériaux

01-10-2021

SL-DRT-21-0728

sebastien.rolere@cea.fr

Health and environment technologies, medical devices (.pdf)

The technical and biological benefits of several additive manufacturing (AM) processes, for the elaboration and production of microfluidic scaffolds used in the development of implantable organ-on-chip, will be investigated during this PhD project. AM technics should lead to the development of new complex 3D microphysiological systems, more representative of the in vivo environment. Furthermore, the PhD student will also focus on the development of new transparent biocompatible and bioresorbable polymer materials compatible with the selected AM technics, for the substitution of currently used polydimethylsiloxane (PDMS). Finally, the model microfluidic chips, based on the components developed in DRF and DRT labs, will be included in biological assessment campaigns.

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development and characterization of conformable piezoelectric materials for medical application

Département des Technologies des NanoMatériaux (LITEN)

Laboratoire Composants Organiques

01-10-2021

SL-DRT-21-0767

mohammed.benwadih@cea.fr

Health and environment technologies, medical devices (.pdf)

Recent advances in materials, manufacturing, biotechnology, and systems have favored many sensors and actuators based on flexible, biocompatible piezoelectric materials in medical fields.In this internship, the principles, the future opportunities and challenges in the development and characterization of conformable piezoelectric materials for medical use will be examined. An expandable piezoelectric sensor / actuator, made on a stretchable substrate, will be developed with materials (composites / polymers) deposited by printing methods. These developments will make it possible to study the feasibility of using such piezoelectric components in the field of medicine. The PhD student, with the teams in place, will develop a piezoelectric component on a stretchable substrate, via (i) the use of an intrinsically stretchable piezoelectric polymer or via (ii) the implementation of composite materials (inorganic piezoelectric particles in a matrix polymer). The intern will also have electrical characterization work to be carried out on these components. This internship will take place as part of a collaboration between the LGEF laboratory of INSA LYON for piezoelectric characterizations and CEA_Liten for material choice / process development aspects and material characterization.

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Development of biosensors for early detection of pest insects using pheromone receptor-based olfactory sensors

Département Métrologie Instrumentation et Information (LIST)

Laboratoire Capteurs Diamants

01-10-2021

SL-DRT-21-0912

emmanuel.scorsone@cea.fr

Health and environment technologies, medical devices (.pdf)

This work will be carried out within the framework of the Priority Research Program "Cultivate and Protect Otherwise" project PPRCPA-PheroSensor (Early detection of insect pests using olfactory sensors using pheromonal receptors). This project, which will start in April 2021 for a duration of 5 years, is led by INRAE-UMR 1392 iEES in collaboration with INRAE-UR 1404 MaiAGE, CNRS-LORIA, ESIEE-Paris Université Gustave Eiffel, EGCE?IRD and CEA-LIST. Insects (in)directly destroy 1/3 of the world's annual harvests. Climate change and increased trade make the early detection of invasive insect pests a major challenge for optimal action before infestation. Insects use specific pheromones to attract congeners of the other sex (sex pheromones, e.g. moths) or both sexes (aggregation pheromones, e.g. weevils). These compounds are used to lure insects into traps, with the number of captures indicating population levels. This monitoring method has drawbacks: it requires frequent human intervention (counting / identification of catches) and an attractive pheromone diffusion, which is sometimes difficult to maintain. Detecting insect pheromones is an alternative for insect monitoring, but a challenge due to the low amounts emitted. PheroSensor will go beyond the most advanced odor detection technologies by developing innovative bio-inspired sensors to detect harmful insects.

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