Scientific direction Development of key enabling technologies
Transfer of knowledge to industry

PhD : selection by topics

Sciences pour l'ingénieur >> Chimie physique et électrochimie
2 proposition(s).

Stretchable conductive hydrogel electrodes for soft tissue stimulation

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Chimie des Matériaux et des Interfaces

01-09-2017

SL-DRT-17-0298

isabelle.texier-nogues@cea.fr

The development of biocompatible, flexible and stretchable electronic devices for soft tissue stimulation is a great challenge. The main goal of the PhD is the design and study of new electrode materials which originality lies in the combination of two crosslinked polysaccharide systems incorporating a conducting polymer. These organic conductive tracks will be deposited on stretchable chitosan-PEG films whose mechanical properties can be well controlled. The electrical, mechanical, and structural properties of the materials will be characterized. Their biocompatibility will be assessed by standard assays, and the electrodes will be tested in rodents (targeted application: treatment of chronic back pain). These biocompatible stretchable electrodes will allow for this application to i) improve the lifetime of implants by reducing the risks of material rupture due to fatigue or excessive stretching, ii) improve tissue adhesion to the electrode, and iii) prevent scar tissue formation. In general, such conductive stretchable materials would be of high interest to overcome different challenges (stretchability, flexibility, biocompatibility) in the design of implanted or portable biosensors.

3D porous materials for the design of sequential fluidic bioreactors

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Biologie et Architecture Microfluidiques

01-10-2017

SL-DRT-17-0753

frederic.revol-cavalier@cea.fr

3D porous materials are currently used for their intrinsic structural properties that offers exceptional surface/volume ratio. This property allows rapid exchanges between a processed fluid and the macroporous surface. Moreover, the use of deformable (compression, stretching?) macroporous materials enables easy management of filling and the extraction of fluids through reduction or increase of the internal volume under mechanical stress. These deformable macroporous 3D structures represent a new class of materials of high interest for the design of electrochemical bioreactors. Indeed, the intrinsic open-porosity could be used for the confinement of biological species (enzymes or cells), transforming each pore into single microreactor. Moreover, this 3D macroporous structure could benefit from further implementation of electronic conductivity to the structural material to generate volume 3D electrodes. This thesis deals first with the development of conducting, biocompatible and deformable 3D macroporous-materials in the perspective of enzymatic or cell bioreactor design. These materials will bring original insights on in situ monitoring of cell cultures or on the design of highly sensitive biosensors. Thereby, in a second step the thesis will consist on the functionalization of the macroporous structures and on the design of the bioreactors. The applicant should presents a strong background on materials sciences (and especially macropourous deformable materials) and electrochemistry. Some knowledges on biology/biochemistry and microfluidic would be positive.

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