Scientific direction Development of key enabling technologies
Transfer of knowledge to industry

PostDocs : selection by topics

Technological challenges >> Health and environment technologies, medical devices
4 proposition(s).

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Postdoctoral fellow in AI, real time signal processing and software for real time epilepsy prediction/forecasting for closed loop neuromodulation by focal Cooling.

Clinatec (LETI)

Clinatec (LETI)

01-03-2021

PsD-DRT-21-0023

napoleon.torres-martinez@cea.fr

To date seizure suppression stimulation technologies (electrical stimulation) are majorly based on seizure detection procedure. No study has provided sound evidence that prospective seizure prediction/forecasting can be used to trigger closed loop therapeutics for drug resistant epilepsy treatment. Our proposal is based on the existing motor brain-computer interface algorithms already in clinical use. They can be adapted to generate prediction/forecasting of seizures occurrence. Our working hypothesis is that treating during high-risk seizures periods and not during the actual seizure would require relatively minor doses of the therapeutical element. This will reduce the power consumption and open the door to fully implantable system. Decoding algorithms will be potentially redesigned to respond better to the epileptic seizures forecasting task. They will be compared to the state of the art CNN based approaches, and other approaches. Prediction/forecasting seizures algorithms will be evaluated in an epilepsy model established at Clinatec, using non-human primates, and the algorithms will be refined over time. Cooling the epileptic foci is an effective way to stop de seizure before generalization. This model allows us to test the efficacy of the algorithms in treating focal seizures. An assessment of hardware embedding design constraints would be conducted to facilitate next steps for the clinical device development. The project will benefit from a collaboration between Clinatec and DSYS/SSCE; and will be in line with upcoming activities of LETI's artificial intelligence platform.

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Measurement of active cell nematics by lensless microscopy

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Systèmes d'Imagerie pour le Vivant

01-03-2020

PsD-DRT-20-0059

cedric.allier@cea.fr

At CEA-Leti we have validated a video-lens-free microscopy platform by performing thousands of hours of real-time imaging observing varied cell types and culture conditions (e.g.: primary cells, human stem cells, fibroblasts, endothelial cells, epithelial cells, 2D/3D cell culture, etc.). And we have developed different algorithms to study major cell functions, i.e. cell adhesion and spreading, cell division, cell division orientation, and cell death. The research project of the post-doc is to extend the analysis of the datasets produced by lens-free video microscopy. The post-doc will assist our partner in conducting the experimentations and will develop the necessary algorithms to reconstruct the images of the cell culture in different conditions. In particular, we will challenge the holographic reconstruction algorithms with the possibility to quantify the optical path difference (i.e. the refractive index multiplied by the thickness). Existing algorithms allow to quantify isolated cells. They will be further developed and assessed to quantify the formation of cell stacking in all three dimensions. These algorithms will have no Z-sectioning ability as e.g. confocal microscopy, only the optical path thickness will be measured. We are looking people who have completed a PhD in image processing and/or deep learning with skills in the field of microscopy applied to biology.

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3D dose distribution measurements for electronic brachytherapy treatments using the INTRABEAM system

Département Métrologie Instrumentation et Information (LIST)

Laboratoire de Métrologie de la Dose

01-06-2021

PsD-DRT-21-0093

christel.stien@gmail.com

Electronic brachytherapy is a cancer treatment technique using low energy X-rays (50 keV) generated by miniaturized X-ray tubes positioned in contact with the tissues to be irradiated. In France, the most widespread system is INTRABEAM provided by Zeiss. A dozen French medical services are equipped and use it mainly to treat breast cancer. Despite the advantages of electronic brachytherapy, its use is currently limited by the fact that each system has its own calibration method in terms of absorbed dose to water, which is not, in most cases, traceable to a national metrology standard. It is therefore necessary to develop and implement a generic and robust calibration methodology, as well as suitable measurement procedures for the quality control and verification of the treatment planning systems for electronic brachytherapy treatments. The LNHB, which is the French metrology laboratory for ionizing radiation, is involved in the European metrology project 18NRM02 PRISM-eBT ?Primary standards and traceable measurement methods for X-ray emitting electronic brachytherapy devices? which aims at providing solutions in this direction. The proposed subject fits into the context of this project. The objective of the proposed work is to measure the distributions of absorbed dose in water in 3 dimensions around the INTRABEAM source equipped with its spherical applicator dedicated to breast cancer treatments. For this, dosimetric gels will be used. They consist in radiosensitive gels, which can be read either by Magnetic Resonance Imaging (MRI) or by optical tomography.

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Fast-scintillator-based device for on-line FLASH-beam dosimetry

Département Métrologie Instrumentation et Information (LIST)

Laboratoire Capteurs et Architectures Electroniques

01-12-2020

PsD-DRT-20-0127

dominique.tromson@cea.fr

New cancer treatment modalities aim to improve the dose delivered to the tumor while sparing healthy tissue as much as possible. Various approaches are being developed, including the temporal optimization of the dose delivered with very high dose rate irradiation (FLASH). In this particular case, recent studies have shown that FLASH irradiation with electrons was as effective as photon beam treatments for tumor destruction while being less harmful to healthy tissue. For these beams, the instantaneous doses are up to several orders of magnitude higher than those produced by conventional beams. Conventional active dosimeters saturate under irradiation conditions at very high dose rates per pulse, therefore on-line dosimetry of the beam is not possible. We propose to develop a dosimeter dedicated to the measurement of beams in FLASH radiotherapy based on an ultra-fast plastic scintillator coupled with a silicon photomultiplier sensor (SiPM). The novelty of the project lies both in the chemical composition of the plastic scintillator which will be chosen for its response time and its wavelength emission to have a response adapted to the impulse characteristics of the beam, and in the final sensor with the possibility of coupling the plastic scintillator to a miniaturized SiPM matrix. The final goal is to be able to access, with a reliable methodology, the dosimetry and in-line geometry of FLASH beams.

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