Transfer of knowledge to industry
Département Systèmes (LETI)
Laboratoire Autonomie et Intégration des Capteurs
01-01-2021
PsD-DRT-21-0004
Technologies pour la santé et l'environnement, dispositifs médicaux (.pdf)
This project is part of the development of remotely controllable micro-robots for non-invasive surgery of the future. One of the main technological challenges limiting the integration of sensors and actuators is the lack of on-board energy. The project consists of developing a wireless power transmission technology while maintaining control of the robot's spatial position. The first step will be to demonstrate the feasibility of transmitting high power while manipulating the robot in three dimensions. The system comprising a magnetic coil platform and the magnetic robot will be modelled (analytical modelling, finite element simulation, etc.) in order to assess the influence of the main parameters and the limits of the technology and compare them with the literature. After the system dimensioning, it will be fabricated and assembled by integrating the magnetic platform, the power system, the control and the graphical interfaces to achieve a first demonstrator with a basic robot. The second step will consist in demonstrating the remote power supply of sensor-actuator functions that are of interest for biomedical applications. Different sensors and actuators will be integrated with their electronics, and these functions will be demonstrated in a representative environment. The post-doctoral student will be in charge of the technical realisation of the project and will be a source of innovative solutions. He (she) will be able to rely on a team of experts, as well as on the electronics and mechatronics engineers of the laboratory for the realisation of the system. It is expected that the post-doctoral student will promote his/her work through scientific publications, patent applications and participation at conferences.
Clinatec (LETI)
Clinatec (LETI)
01-03-2021
PsD-DRT-21-0023
napoleon.torres-martinez@cea.fr
Technologies pour la santé et l'environnement, dispositifs médicaux (.pdf)
To date seizure suppression stimulation technologies (electrical stimulation) are majorly based on seizure detection procedure. No study has provided sound evidence that prospective seizure prediction/forecasting can be used to trigger closed loop therapeutics for drug resistant epilepsy treatment. Our proposal is based on the existing motor brain-computer interface algorithms already in clinical use. They can be adapted to generate prediction/forecasting of seizures occurrence. Our working hypothesis is that treating during high-risk seizures periods and not during the actual seizure would require relatively minor doses of the therapeutical element. This will reduce the power consumption and open the door to fully implantable system. Decoding algorithms will be potentially redesigned to respond better to the epileptic seizures forecasting task. They will be compared to the state of the art CNN based approaches, and other approaches. Prediction/forecasting seizures algorithms will be evaluated in an epilepsy model established at Clinatec, using non-human primates, and the algorithms will be refined over time. Cooling the epileptic foci is an effective way to stop de seizure before generalization. This model allows us to test the efficacy of the algorithms in treating focal seizures. An assessment of hardware embedding design constraints would be conducted to facilitate next steps for the clinical device development. The project will benefit from a collaboration between Clinatec and DSYS/SSCE; and will be in line with upcoming activities of LETI's artificial intelligence platform.
Département Microtechnologies pour la Biologie et la Santé (LETI)
Laboratoire Chimie, Capteurs et Biomatériaux
01-03-2021
PsD-DRT-21-0058
Technologies pour la santé et l'environnement, dispositifs médicaux (.pdf)
Electrochemical sensors are commonly used for water analysis because of their sensitivity, their versatility, and their relative simplicity of implementation at the instrumental level. However, their large-scale deployment for continuous monitoring of water resources as well as discharges resulting from agricultural, industrial or residential activities is severely limited by the lifetime of the sensors. This is directly related to the durability of the materials used but also to the fouling of the electrodes during immersion. Currently, diamond electrodes as developed at CEA LIST can overcome these technical limitations (chemical inertia, regeneration of the measurement interface, etc.) but require a manufacturing process that is far too costly for the vast majority of the applications identified. Amorphous carbon (known under the terminology "DLC" for "Diamond Like Carbon") seems to have similar technical characteristics to diamond, for a manufacturing cost 10 to 20 times less. The aim of this project is to demonstrate the interest of this new electrode material for water analysis in the field, to increase its analytical capacities (selectivity, sensitivity) by adding inorganic catalysts and to define a low-cost production process. Symbolically - but in line with user demands - the aim is to achieve a maintenance-free service life of one year for an autonomous system for monitoring drinking water distribution networks. The performances will be validated on a reduced set of representative sensors, for which there is a high demand (pH, free chlorine, nitrate) or which are of strong societal interest (chlorophenols, used in many pesticides).
Département Microtechnologies pour la Biologie et la Santé (LETI)
Laboratoire Systèmes d'Imagerie pour le Vivant
01-03-2020
PsD-DRT-20-0059
Technologies pour la santé et l'environnement, dispositifs médicaux (.pdf)
At CEA-Leti we have validated a video-lens-free microscopy platform by performing thousands of hours of real-time imaging observing varied cell types and culture conditions (e.g.: primary cells, human stem cells, fibroblasts, endothelial cells, epithelial cells, 2D/3D cell culture, etc.). And we have developed different algorithms to study major cell functions, i.e. cell adhesion and spreading, cell division, cell division orientation, and cell death. The research project of the post-doc is to extend the analysis of the datasets produced by lens-free video microscopy. The post-doc will assist our partner in conducting the experimentations and will develop the necessary algorithms to reconstruct the images of the cell culture in different conditions. In particular, we will challenge the holographic reconstruction algorithms with the possibility to quantify the optical path difference (i.e. the refractive index multiplied by the thickness). Existing algorithms allow to quantify isolated cells. They will be further developed and assessed to quantify the formation of cell stacking in all three dimensions. These algorithms will have no Z-sectioning ability as e.g. confocal microscopy, only the optical path thickness will be measured. We are looking people who have completed a PhD in image processing and/or deep learning with skills in the field of microscopy applied to biology.
Département Métrologie Instrumentation et Information (LIST)
Laboratoire Capteurs et Architectures Electroniques
01-12-2020
PsD-DRT-20-0127
Technologies pour la santé et l'environnement, dispositifs médicaux (.pdf)
New cancer treatment modalities aim to improve the dose delivered to the tumor while sparing healthy tissue as much as possible. Various approaches are being developed, including the temporal optimization of the dose delivered with very high dose rate irradiation (FLASH). In this particular case, recent studies have shown that FLASH irradiation with electrons was as effective as photon beam treatments for tumor destruction while being less harmful to healthy tissue. For these beams, the instantaneous doses are up to several orders of magnitude higher than those produced by conventional beams. Conventional active dosimeters saturate under irradiation conditions at very high dose rates per pulse, therefore on-line dosimetry of the beam is not possible. We propose to develop a dosimeter dedicated to the measurement of beams in FLASH radiotherapy based on an ultra-fast plastic scintillator coupled with a silicon photomultiplier sensor (SiPM). The novelty of the project lies both in the chemical composition of the plastic scintillator which will be chosen for its response time and its wavelength emission to have a response adapted to the impulse characteristics of the beam, and in the final sensor with the possibility of coupling the plastic scintillator to a miniaturized SiPM matrix. The final goal is to be able to access, with a reliable methodology, the dosimetry and in-line geometry of FLASH beams.
