Scientific direction Development of key enabling technologies
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Engineering science >> Instrumentation
2 proposition(s).

Diamond membrane based microdosimetric system for radiation quality assurance in hadron therapy

DM2I (LIST)

Laboratoire Capteurs Diamants

01-03-2019

PsD-DRT-19-0042

michal.pomorski@cea.fr

The Diamond Sensors Laboratory of CEA-LIST has twenty years of experience in diamond material synthesis including R&D on diamond-based sensors and radiation-detection devices. The INSERM-funded (2018-2020) DIADEM collaboration proposes to develop a new tissue-equivalent diamond-based micro-dosimeter with associated electronics, to obtain precise measurements of lineal energy distributions in hadron-therapy clinical conditions with high rates and high spatial resolution. Interdisciplinary experimental techniques, such as nano- and microfabrication, device characterization under ion nuclear microprobes micro-electronic and electronic developments are going to be employed for diamond micro-dosimeter prototyping. The performance of final prototypes will be evaluated with clinical hadron beams leading to first step for the implementation in radiobiological numerical models. The position: ? MC simulations of clinical proton/carbon beams interactions with matter, to benchmark experimental response of the micro-dosimeter prototypes ? participation in beamtimes for devices testing with clinical beams and parcticle microbeams at accelerator facilities ? participation in fabrication process of the devices (surfaces preparation, thin layer deposition, photolithography) Requirements: ? PhD in physics/medical physics or equivalent ? knowledge of solid-state particle detectors, associated electronics and signal processing, possibly including some experience at accelerator facilities ? knowledge of relevant Monte Carlo simulation programs ? verbal and written communication in English (French would be additional asset) ? knowledge of simple printed circuit boards design and semiconductors simulation software would be an asset Conditions: A one-year postdoctoral contract starting preferably from March-April 2019. Salary and benefits are commensurate with those of CEA organization. Classification is based upon candidate's qualification and assigned duties.

Microfluidics for a human Pancreas-on-a chip

Département Microtechnologies pour la Biologie et la Santé (LETI)

Laboratoire Biologie et Architecture Microfluidiques

01-05-2019

PsD-DRT-19-0083

yves.fouillet@cea.fr

The context of the project concerns the microsystems for biology whose stakes are the integration and the automation of protocols assays for healthcare applications. In this field there is a growing interest on the development of organs on chips. An organ-on-a-chip is a microfluidic cell culture device created with micro-manufacturing technics. The fluidics networks create the mimicking in vivo environment for cell culture such as perfusions and physiologic stimulation, thus making it possible to have biological models more relevant than those currently available. The goal is to engineer a microfluidic platform that can recapitulate functional units of human pancreas.

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